Point: Intensive Glycemic Control and Mortality in ACCORD--A Chance Finding?
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منابع مشابه
Point: Intensive Glycemic Control and Mortality in ACCORD—A Chance Finding?
The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was designed to assess whether intensive glucose management aimed at a normal A1C ( 6%) versus standard therapy aimed at an A1C of 7–8% would reduce the risk of cardiovascular disease as reflected by the incidence of a major adverse cardiac event (MACE) such as cardiovascular death, nonfatal myocardial infarction, or nonfatal ...
متن کاملIntensive glycemic control in the ACCORD and ADVANCE trials.
Diabetes is associated with a reduced lifespan, largely as a consequence of cardiovascular disease.1-3 Although diabetes significantly increases the risk of cardiovascular events,1 the relative increase in events for each percent increase in glycated hemoglobin is modest.4 Microvascular complications of diabetes remain the leading causes of blindness and renal failure in the developed world and...
متن کاملGenetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial
OBJECTIVE To identify genetic determinants of increased cardiovascular mortality among subjects with type 2 diabetes who underwent intensive glycemic therapy in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. RESEARCH DESIGN AND METHODS A total of 6.8 million common variants were analyzed for genome-wide association with cardiovascular mortality among 2,667 self-reported...
متن کاملIntensive Glycemic Control Is Not Associated With Fractures or Falls in the ACCORD Randomized Trial
OBJECTIVE Older adults with type 2 diabetes are at high risk of fractures and falls, but the effect of glycemic control on these outcomes is unknown. To determine the effect of intensive versus standard glycemic control, we assessed fractures and falls as outcomes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) randomized trial. RESEARCH DESIGN AND METHODS ACCORD participant...
متن کاملCounterpoint: Intensive Glucose Control and Mortality in ACCORD—Still Looking for Clues
E arly cessation of the intensive glycemic treatment arm of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial because of a 22% excess of all-cause mortality compared with the standard arm (1) came as an unpleasant surprise to many observers. Since then, considerable discussion of the significance of this result has ensued along with various theories as to why it occurred. In ...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2010
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc10-1506